Research finds aspirin use linked with increased risk of heart failure

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Taking aspirin increases the risk of heart failure by 26 percent. Other factors associated with this are smoking, obesity, high blood pressure, high cholesterol, diabetes and heart disease.

New Delhi: According to a new research, taking aspirin increases the risk of heart failure by 26 percent. Other factors associated with this are smoking, obesity, high blood pressure, high cholesterol, diabetes and heart disease.


The findings of this research have been published in the ‘ESC Heart Failure Journal’. “This is the first study to report that in individuals with at least one risk factor for heart failure, those taking aspirin were compared with those not using the drug,” said study author Dr. more likely to develop the condition. Freiburg, Germany.


“While the findings require confirmation, they indicate that the potential link between aspirin and heart failure needs to be clarified,” Muazza said.


The effect of aspirin on heart failure is controversial. The aim of this study is to evaluate its relationship with the incidence of heart failure in people with and without heart disease, and to evaluate whether drug use is related to a new diagnosis of heart failure in people at risk. .


The analysis included 30,827 individuals at risk of developing heart failure who were enrolled in the HOMAGE study from Western Europe and the Americas. “At-risk” was defined as one or more of the following: smoking, obesity, high blood pressure, high cholesterol, diabetes and heart disease. Participants were 40 years of age and older and were free of heart failure at baseline. Aspirin use was recorded at enrollment and participants were classified as user or non-user. Participants were followed for the first occurrence of fatal or nonfatal heart failure requiring hospitalization.


The mean age of the participants was 67 years and 34 percent were female. At baseline, a total of 7,698 participants (25 percent) were taking aspirin. During a 5.3-year follow-up, 1,330 participants had developed heart failure.


The investigators considered the use of aspirin and the incidence of heart failure after adjusting for sex, age, body mass index, smoking, alcohol use, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, cardiovascular disease and renin treatment. assessed the relationship between -Angiotensin-aldosterone-system inhibitors, calcium channel blockers, diuretics, beta-blockers, and lipid-lowering drugs. Taking aspirin was independently associated with a 26 percent increased risk of a new heart failure diagnosis.


To examine the consistency of the results, the researchers repeated the analysis after matching aspirin users and non-users for heart failure risk factors. In this matched analysis, aspirin was associated with a 26 percent increased risk of a new heart failure diagnosis. To further examine the results, the analysis was repeated after excluding patients with a history of cardiovascular disease. In 22,690 participants (74 percent) free of heart disease, aspirin use had a 27 percent increased risk of heart failure.


Dr. Mujaz said, “This was the first large study to examine the association between aspirin use and incident heart failure and at least one risk factor in individuals with and without heart disease. Commonly used aspirin – One in four participants in our study was taking the drug. In this population, aspirin use was associated with the occurrence of heart failure, independent of other risk factors.”


They concluded, “larger multinational randomized trials are needed to verify these results in adults at risk of heart failure. Until then, our observations suggest that aspirin should be used with caution in people with heart failure.” or be determined with risk factors for the condition.” (ANI)

First published:November 23, 2021, 4:37 pm

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